This evidence-based nursing care plan for infection control aligns with CDC, WHO, and IDSA guidelines, providing a structured framework to address NANDA-I nursing diagnoses like Hyperthermia and Risk for Infection Spread. Key interventions include sepsis protocols (1-hour antibiotic administration), antimicrobial stewardship, and qSOFA criteria for risk assessment. Integrates Cochrane-reviewed strategies such as non-pharmacological fever management (cooling blankets) and EHR-compatible documentation for real-time tracking. Designed for clinical adaptability, it prioritizes health equity with culturally tailored education and low-resource customization. Targets infection-related outcomes: temp normalization within 24–48 hours, reduced WBC/CRP levels, and discharge readiness via patient competency in hand hygiene and sterile wound care.