Evidence-based COPD nursing care plan integrates NANDA-I diagnoses, Cochrane evidence, and GOLD guidelines for optimal management. Key focus areas: oxygen therapy (targeting SpO₂ 88-92%), airway clearance (nebulized bronchodilators, huff coughing), pulmonary rehabilitation, and infection prevention (vaccinations, hygiene). Includes smoking cessation support and exacerbation action plans to reduce hospitalizations. Clinically validated for accuracy and compliance in diverse healthcare settings.