Nursing interventions transform chronic disease management by integrating evidence-based strategies like personalized patient education (1-2% HbA1c reduction), telehealth monitoring (44% fewer heart failure admissions), and multidisciplinary care coordination (25-50% lower readmissions). Nurses optimize outcomes through preventive protocols (90% fewer diabetic amputations), behavioral support (50% depression reduction), and cost-effective solutions ($8,000–$12,000 annual savings per patient). Proven to boost survival rates (18% lower mortality) and satisfaction (23% higher), these interventions align with value-based care, emphasizing early intervention, technology integration, and holistic support.